Chemo-Enzymatic Cascade for the Generation of Fragrance Aldehydes

In this study, we present the synthesis of chiral fragrance aldehydes, which was tackled by a combination chemo-catalysis and multi-enzymatic in vivo cascade reaction development highly versatile high-throughput assay for enzymatic reduction carboxylic acids. We investigated biocompatible metal-catalyzed preparation ? or ? substituted cinnamic acid derivatives were fed directly into biocatalytic system. Subsequently, target molecules synthesized an consisting carboxylate reduction, followed selective C-C double bond catalyzed appropriate enoate reductases. oxidative Heck protocol combined it with cells expressing reductase from Neurospora crassa (NcCAR) ene Saccharomyces pastorianus production aldehydes.